摘要
Abstract
Objective To investigate the expression of CD146 in osteosarcoma tissues and the relationship with clinical and pathological characteristics. Methods The expression of CD146 and microvessel density (MVD) in 50 cases of osteosarcoma tissues was determined by Immunohistochemistry, and further detecting the expression of CD146 in osteosarcoma tissues by RT-qPCR and Western blot. Results CD146 was overexpressed in Human Osteosarcoma Tissues, and the MVD value was significantly higher than nonmalignant tissue sur ounding in osteosarcoma, and the expression level of CD146 was cor elated with Enncking stage and pulmonary metastasis( <0.01). With the progress of clinical stage and histological dif erentiation of osteosarcoma, expression of CD146 was increased, and expression of CD146 in osteosarcoma with pulmonary metastasis group was significantly higher than those without pulmonary metastasis. Conclusion CD146 is related to the occur ence and development of osteosarcoma closely, and should play an important role in the process.关键词
CD146/骨肉瘤/表达Key words
CD146/Osteosarcoma/Expression
