医学新知杂志Issue(3)：179-182,4.
青蒿素联合全转铁蛋白对乳腺癌 MT40靶向作用
Targeting Effects of Artemisinin Combined with Holo - transferrin on MT40 Cells in Breast Cancer
摘要
Abstract
Objective To explore the targeting effects of artemisinin combined with holo - transferrin on MT40 cells. Methods MTT assay were undertaken to detect the inhibiting effect of MT40 cells exposed to artemisinin only and artemisinin combined with holo - transferrin in different concentration. FCM was used to detect the apoptosis of MT40 cells exposed to artemisinin only and artemisinin combined with holo - transferrin in different concentration. In-hibiting effect of artemisinin in mice transplanted MT40 was also detected. Results Artemisinin had the ability to in-hibite proliferation and induce apoptosis of MT40 cells in different concentration in a dose - dependent manner. The role had been enhanced obviously when artemisinin combined with holo - transferrin. Artemisinin could restrain mice transplanted MT40 in vivo. Conclusion Artemisinin can inhibite proliferation and induce apoptosis of MT40 cells and restrain mice transplanted MT40. The role can be enhanced obviously when artemisinin combined with holo - transfer-rin,which can prove the target role of artemisinin combined with holo - transferrin to MT40 cells in breast cancer.关键词
乳腺癌/青蒿素/全转铁蛋白/靶向治疗Key words
Breast cancer/Artemisinin/Holo - transferrin/Targeted therapy分类
医药卫生引用本文复制引用
余和平,崔乐,王必蓉,潘跃进..青蒿素联合全转铁蛋白对乳腺癌 MT40靶向作用[J].医学新知杂志,2015,(3):179-182,4.基金项目
武汉市卫计委课题 （）
