医药导报Issue(5)：573-574,2.DOI:10.3870/yydb.2014.05.006
玄芷镇痛片对急性血瘀模型大鼠血浆6-酮-前列腺素Flα和血栓素B2的影响
Effects of Xuanzhi Analgesic Tablet on Plasma Levels of 6-K-PGFlαand TXB2 in Rats with Acute Blood Stasis
邹欣 1王开富 1徐丽君 1龚菂 1黄光英1
作者信息
- 1. 华中科技大学同济医学院附属同济医院中西医结合研究所，武汉 430030
- 折叠
摘要
Abstract
Objective To investigate the effects of xuanzhi analgesic tablets on plasma levels of 6-keto-prostaglandin Flα(6-K-PGFlα) and thromboxane B2(TXB2) in rats with acute blood stasis. Methods Sixty SD rats were divided into six groups randomly, namely normal control, model control, positive control, xuanzhi analgesic tablets at 1. 36, 2. 72, and 5. 44 g·kg-1 groups. The rat model of blood stasis syndrome was caused by subcutaneous injection of adrenaline incorporated with ice-bathing. The effects of xuanzhi analgesic tablet on 6-K-PGFlαand TXB2 were observed. Results Compared with the normal control,plasma level of 6-K-PGFlα was significantly reduced(P<0. 01) and that of TXB2 in the model control was evidently increased(P<0. 01). Three dosages of xuanzhi analgesic tablets significantly raised 6-K-PGFlαlevel(P<0. 05)and lowered TXB2 level (P<0. 05). Conclusion Xuanzhi analgesic tablets significantly adjust plasma levels of 6-K-PGFlαand TXB2in rats with acute blood stasis. Xuanzhi analgesic tablets can coreect the imbalance between PGI2 and TXA2 through increasing 6-K-PGFlαand desearing TXB2 levels.关键词
玄芷镇痛片/血瘀,急性/6-酮-前列腺素Flα/血栓素B2Key words
Xuanzhi analgesic tablet/Blood stasis,acute/6-keto-prostaglandin Flα/Thromboxane B2分类
医药卫生引用本文复制引用
邹欣,王开富,徐丽君,龚菂,黄光英..玄芷镇痛片对急性血瘀模型大鼠血浆6-酮-前列腺素Flα和血栓素B2的影响[J].医药导报,2014,(5):573-574,2.
