医药导报Issue(5)：593-596,597,5.DOI:10.3870/yydb.2014.05.012
维生素D对妊娠糖尿病胰岛素敏感性脂肪因子及肿瘤坏死因子-α的影响
Effects of Vitaimin D on Insulin Sensitivity and the Adipokine Factors APN,Visfatin, RBP4,TNF-αin Patients with Gestational Dellitus Mellitus
张黎明 1高凌 1帅红霞 1润袁敏 1邓晨盺 1田源 1马计 1肖婧1
作者信息
- 1. 湖北文理学院附属医院内分泌科，襄阳 441021
- 折叠
摘要
Abstract
Objective To investigate the relationship and mechanism of the serum vitamin D levels with insulin sensitivity and adipokines APN,RBP4,visfatin and TNF-α in patients with gestational diabetes mellitus(GDM). Methods A total of 101 patients with gestational diabetes( GDM group) and 50 pregnant women with normal blood sugar( control group) were recruited to detect the serum levels of correlative biochemical indexes,APN,RBP4,visfatin,TNF-α and 25OHD3 using an HPLC method. Twenty-four patients in the GDM group diagnosed with vitamin D deficiency(<25 nmol·L-1 ) were randomized to receive either 1,25(OH) 2D3(0. 25 μg·d-1) orally or no treatment. Serum levels of correlative biochemical indexes were detected after 1 month. Results GDM patients had 25OHD3 levels significantly lower than the control group(P<0. 05),APN levels lower than the control group,and RBP4,visfatin,TNF-α levels significantly higher than the control group(all P<0. 05). After 1 month of 1,25(OH) 2D3 treatment,HOMA-IR increased,while HOMA-β decreased. APN levels was positively correlated(r= 0. 526) with 25OHD3;RBP4,visfatin,TNF-α decreased and were negatively correlated with 25OHD3( r values were -0. 272,-0. 153,-0. 072). Conclusion Vitamin D can reduce the adipokines RBP4,visfatin,TNF-α,increase APN,and thus play a protective role for gestational diabetes.关键词
维生素D/糖尿病,妊娠/胰岛素敏感性/脂联素/内脂素/视黄醇结合蛋白/肿瘤坏死因子Key words
Vitamin D/Diabetes,gestational/Insulin sensitivity/Adiponectin/Retinol binding protein/Tumor necrosis factor分类
医药卫生引用本文复制引用
张黎明,高凌,帅红霞,润袁敏,邓晨盺,田源,马计,肖婧..维生素D对妊娠糖尿病胰岛素敏感性脂肪因子及肿瘤坏死因子-α的影响[J].医药导报,2014,(5):593-596,597,5.
