医药导报Issue(5)：664-667,4.DOI:10.3870/yydb.2014.05.035
聚乙二醇6000对间尼索地平溶解性能的影响
Influences of Polyethylene Glycol6000 on the Solubility of m-Nisoldipine
摘要
Abstract
Objective To investigate the influences of polyethylene glycol on the solubility and in vitro dissolution of m-nisoldipine,which could provide guidance for chosing formulations of m-nisoldipine. Methods Solid dispersions of m-nisoldipine were prepared by solvent-melting method with polyethylene glycol6000 matrix. DSC and XRD spectroscopy were applied to identify the solid dispersions. The solubility and in vitro dissolution were detected by UV spectroscopy. Results The DSC and XRD map were different from the crude drug and their physical mixtures. The dissolution rates(13,15,17) were faster(35. 31%,38. 71%,41. 48%) than that of the crude drug(26. 80%),and the dissolution rates of the solid dispersions in the same ratio were higher than the physical mixtures. Conclusion DSC analysis indicated that eutectic compounds were produced by the m-nisoldipine and polyethylene glycol,in which polyethylene glycol6000 acts as a carrier. The solubility and in vitro dissolution of m-nisoldipine can be increased.关键词
间尼索地平/聚乙二醇6000/体外溶出/差示扫描量热分析/X射线粉末衍射光谱Key words
m-Nisoldipine/Polyethylene glycol-6000/In vitro dissolution/Differential scanning calorimetry/X-ray powder diffraction分类
医药卫生引用本文复制引用
石晓伟,孙萌萌,王静,杨彩琴..聚乙二醇6000对间尼索地平溶解性能的影响[J].医药导报,2014,(5):664-667,4.基金项目
河北省教育厅自然科学研究计划项目(2009148) （2009148）
河北省卫生厅医学科学研究重点课题(20090059) （20090059）
