医药导报Issue(5)：668-671,4.DOI:10.3870/yydb.2014.05.036
经典恒温法和多元线性模型预测头孢甲肟在输液中的热稳定性
Detecting Thermal Stability of Cefmenoxime Hydrochloride in Infusion Solutions by Classical Isothermal Kinetic Method and Multivariate Linear Model
摘要
Abstract
Objective To investigate thermal degradation kinetic characteristics of Cefmenoxime Hydrochloride in infusion solutions, and predict its thermal stability. Methods The HPLC was applied to determine the contents of Cefmenoxime Hydrochloride. Classical isothermal kinetic method and multivariate linear model were used to predict the expiration date of the injection. Results It was found that the thermal degradation kinetics of Cefmenoxime Hydrochloride in two infusion solutions corresponded with the first-order kinetics. The expiration dates of Cefmenoxime Hydrochloride in 0. 9%sodium chloride injection calculated by two different methods were 2. 20 days and 1. 52 days,and in 5% glucose injection were 2. 09 days and 1. 53 days,respectively. Conclusion The thermal stability of Cefmenoxime Hydrochloride in infusion solutions is poor and its expiration dates are the same calculated by two different methods.关键词
头孢甲肟/热降解动力学/经典恒温法/多元线性模型/色谱法,高效液相Key words
Cefmenoxime/Thermal degradation kinetic/Classical isothermal kinetic method/Multivariate linear model/HPLC分类
医药卫生引用本文复制引用
王建欣,张辰辰,杨继章,谷体心..经典恒温法和多元线性模型预测头孢甲肟在输液中的热稳定性[J].医药导报,2014,(5):668-671,4.基金项目
河北省医学科学研究重点课题(20120276) （20120276）
