医药导报Issue(6)：699-702,4.DOI:10.3870/yydb.2014.06.002
雷贝拉唑抑制胃酸分泌的药动学-药效学结合研究
Combined Pharmacokinetics-pharmacodynamics Study of Rabeprazole in Inhibition of Gastric Acid Secretion
摘要
Abstract
Objective To investigate the pharmacokinetics ( PK ) and pharmacodynamics ( PD ) processes of rabeprazole in inhibiting gastric acid secretion with the combined PK-PD model. Methods A total of 10 healthy volunteers were given a intravenous infusion of 20 mg rabeprazole over a 30-min period. The concentration of rabeprazole in the plasma at different time points was detected by HPLC,and the PK parameters were calculated by DAS 2. 0 software. At the same time the intragastric pH was monitored over 24 hours to fit the PD parameters with indirect inhibition model. Results The main PK parameters,t1/2,Cmax,and AUC were(60. 5±17. 3)min,(1 299. 1±201. 0)ng·mL-1,and(106. 4±26. 0)mg·min·L-1, respectively.The corresponding PD parameters,Kin,Ke,IC50 and Imax were(8.200±3.362)h-1,(1.080±0.378)h-1,(0.286± 0. 129)mg·L-1 and(6. 93± 2. 15)pH,respectively. Conclusion The PK of rabeprazole in healthy volunteers conforms to one compartment model,and the PD fits the indirect response inhibition model. The equation can effectively establish the relationship between the blood drug concentration and the effect.关键词
雷贝拉唑/药动学-药效学结合/抑制模型/间接反应Key words
Rabeprazole/Pharmacokinetics and pharmacodynamics combination/Inhibition model/indirect分类
医药卫生引用本文复制引用
袁红宇,王永庆,张宏文,孟玲,郝琨..雷贝拉唑抑制胃酸分泌的药动学-药效学结合研究[J].医药导报,2014,(6):699-702,4.基金项目
江苏省卫生厅医学科技发展基金临床药学研究科技项目 （）
