医药导报Issue(6)：703-707,5.DOI:10.3870/yydb.2014.06.003
玉郎伞查尔酮对异丙肾上腺素致小鼠心室重构的保护作用
Protective Effects of 17-Methoxyl-7-hydroxy-benzene-furabcgakcone on Isoproterenol-induced Ventricular Remodeling in Mice
摘要
Abstract
Objective To investigate the effects of 17-methoxyl-7-hydroxy-benzene-furabcgakcone( MHBFC ) on isoproterenol-induced ventricular remodeling in mice. Methods Isoproterenol(ISO)was given subcutaneously(1 mg·kg-1, twice per day for 7 d)to induce ventricular remodeling in mice. Mice were divided into normal control group,model group, captopril group,MHBFC low and high-dose groups. 65 mg·kg-1 captopril was given by intragastric administration in captopril group,2. 5,5. 0 mg·kg-1 MHBFC were given by intravenous injection in MHBFC low and high-dose groups. At the end of the 7th day,the hearts of the mice were weighted,and myocardial hypertrophy index was expressed as heart weight/body weight, double kidneys weight/body weight and lung weight/body weight( HW/BW,KW/BW and LW/BW). Colorimetric method was used to determine the content of hydroxyproline( Hyp)in heart,the activity of superoxide dismutase( SOD)and the content of malondialdehyde( MDA)in serum. The histological changes were observed by HE and Masson’s staining,the changes of cross section area( CSA),collagen volume fraction,( CVF)and perivascular circumferential collagen area( PVCA)were determined. Results Compared with the model group,MHBFC potently inhibited cardiomyocyte hypertrophy,decreased the HW/BW, KW/BW and LW/BW,improved cardiac pathology changed,increased the of activity SOD,decreased the content of MDA in serum and the content of Hyp in heart tissue(P﹤0. 01 or P﹤0. 05),decreased the CVF and PVCA(P﹤0. 01). Conclusion MHBFC possesses protective effects against ISO-induced ventricular remodeling in mice,which may be related to its actions in reducing the oxidative stress and improving the antioxidant activity of the body.关键词
玉郎伞查尔酮/异丙肾上腺素/心室重构Key words
17-methoxyl-7-hydroxy-benzene-furanchalcone/Isoproterenol/Ventricular remodeling分类
医药卫生引用本文复制引用
黄建春,刘聪慧,周欢欢,谭丽凤,黄建静,李典鹏,黄仁彬..玉郎伞查尔酮对异丙肾上腺素致小鼠心室重构的保护作用[J].医药导报,2014,(6):703-707,5.基金项目
广西植物功能物质研究与利用重点实验室开放基金资助（ FPRU2013-3）；广西自然科学基金资助项目（2013GXNSFAA019175）；2012年优秀博士学位论文培育项目 （）
