医药导报Issue(7)：858-862,5.DOI:10.3870/yydb.2014.07.005
菝葜不同浓度乙醇提取物的抗炎活性筛选
Screening of the Different Concentrations of Ethanol Extracts from Smilax China for Its Antiinflammatory Activity
摘要
Abstract
Objective To study the effects of the different concentrations of ethanol extracts of Smilax China on ear edema in mice and granuloma in rats,and to provide an evidence for optimizing the extraction process. Methods Effects of different concentrations of ethanol extracts of Smilax China on the xylene-induced ear edema in mice and the cotton ball-induced granuloma hyperplasia in rats were tested . Results Compared with the model controls,70% ethanol extracts of Smilax China at high,medium and low doses significantly inhibited ear edema in mice (t=2. 58,P<0. 05;t=2. 28,P<0. 05;t=2. 17,P<0. 05) and reduced the granuloma hyperplasia in rats(t=5. 28,P<0. 01;t=5. 24,P<0. 01;t=5. 17,P<0. 01). Conclusion The 70% ethanol extracts of Smilax China at three doses present the most active antiinflammatory effect,confirmed in both mice ear edema and rats granuloma models.关键词
菝葜/乙醇提取物/肿胀,耳/肉芽肿Key words
Smilax China/Ethanol extracts/Edema, ear/Granuloma分类
医药卫生引用本文复制引用
罗艳琴,马云,宋路瑶,秦飞,范银洲,侯连兵..菝葜不同浓度乙醇提取物的抗炎活性筛选[J].医药导报,2014,(7):858-862,5.基金项目
2014A14)*广东省医院药学研究基金(奥赛康基金) （奥赛康基金）
