医药导报Issue(7)：869-873,5.DOI:10.3870/yydb.2014.07.008
祖卡木颗粒大鼠灌胃长期毒性研究
Studies on the Chronic Toxicity of Zukamu Granules in Rats
窦勤 1闫明 2李柯翱 1李治建 2热比姑丽·伊斯拉木 3艾西木江·热甫卡提 1季志红2
作者信息
- 1. 新疆维吾尔自治区维吾尔医药研究所，乌鲁木齐 830049
- 2. 新疆维吾尔医方剂学实验室，乌鲁木齐830049
- 3. 新疆奇康哈博维药有限公司，乌鲁木齐 830001
- 折叠
摘要
Abstract
Objective To study the chronic toxicology of Zukamu granules in rats. Methods A total of 120 healthy SD rats ( male female = 1 1 ) were randomly divided into the control, low ( 0. 72 g · kg-1 · d-1 ), middle (1.43 g·kg-1·d-1),and high (2.86 g·kg-1·d-1) doses of Zukamu granules. The drug was given orally,once daily for a month,and the controls were given with sodium carboxymethyl cellulose. A 2-week recovery period was allowed after the drug withdrawal. Results Three rats in the high dose group developed diarrhea and loose stools for one day. Compared with the control group,the white blood cells ( WBC) ,red blood cells ( RBC) ,hemoglobin ( HGB) ,hematocrit ( HCT) and chlorine ( Cl-) in the high dose group increased. Prothrombin time ( PT ) , blood urea nitrogen ( BUN ) , alanine aminotransferase ( ALT ) , cholesterol(CHO),and aspartate aminotransferase (AST) decreased markededly in the low,middle and high dose group. No obvious change was found in histopathological examination. Conclusion No obvious toxicity was observed in SD rats treated with Zukamu granules at 1. 4g·kg-1·d-1(equivalently to crude drug of 20. 8 g·kg-1·d-1) given orally for one month.关键词
祖卡木颗粒/大鼠/毒性/长期Key words
Zukamu granula/Rat/Toxicity, chronic分类
医药卫生引用本文复制引用
窦勤,闫明,李柯翱,李治建,热比姑丽·伊斯拉木,艾西木江·热甫卡提,季志红..祖卡木颗粒大鼠灌胃长期毒性研究[J].医药导报,2014,(7):869-873,5.
