医药导报Issue(7)：926-931,6.DOI:10.3870/yydb.2014.07.024
连杖微乳的制备工艺
Preparation of Lianzhang Microemulsion
林丽 1银杉杉 1刘磐 1朱莉 2陈威 3林吉 1张军1
作者信息
- 1. 广州中医药大学新药开发研究中心，广州 510006
- 2. 广东药学院，广州 510006
- 3. 广州医药研究总院有限公司，广州 510240
- 折叠
摘要
Abstract
Objective To prepare lianzhang microemulsion and investigate its physicochemical properties. Methods The formulation was optimized with the pseudo-ternary phase diagrams drawn in a titration method. The process parameters were screened by a single factor test, and the physical and chemical properties of the microemulsion were preliminarily studied. Results The formulation of lianzhang microemulsion was as follows:copts root extracts:polygonum cuspidatum extractstea oilEL35 propylene glycolwater as 11. 417721. The microemulsion was obtained with mean diameter of 30. 9 nm by stirring the solution for 20 min at 1 400 r·min-1 and 75 ℃. The particles were uniformly distributed,and the microemulsion was clear and transparent without turbidity,phase separation and precipitation after the temperature test and acceleration test. Conclusion The preparation technology of lianzhang microemulsion is simple and stable.关键词
连杖微乳/制备工艺/质量评价Key words
Lianzhang microemulsion/Preparation technology/Quality evaluation分类
医药卫生引用本文复制引用
林丽,银杉杉,刘磐,朱莉,陈威,林吉,张军..连杖微乳的制备工艺[J].医药导报,2014,(7):926-931,6.
