医药导报Issue(9)：1136-1139,4.DOI:10.3870/yydb.2014.09.005
五味子木脂素对多柔比星诱导肝损伤大鼠的保护作用
Protective Effects of Schisandra Lignans Against Doxorubicin-Induced Liver Injury in Rats
摘要
Abstract
Objective To investigate protective effects of schisandra lignans on doxorubicin-induced liver injury in rats. Methods SD rats were randomly divided into six groups: normal control, model control, vitamin C and schisandra lignans at small, middle, and high doses. The liver injury model was established by intraperitoneal injection of doxorubicin. Normal controls were intragastrically administrated with 0. 9%sodium chloride solution,while other groups were administrated with different medications,respectively. Interleukin-10 (IL-10) in serum,nitric oxide (NO) and aspartate aminotransferase (AST) in liver tissue homogenate were measured. Histopathological changes in hepatic tissues were also observed. Results Serum IL-10 and tissue NO were obviously lower in the model control group than those in other groups,while those in all schisandra lignans treated groups were significantly improved (P<0. 05, P<0. 01). The AST level in schisandra lignans middle- and high dose groups was (372. 58±105. 80) and (327. 92±42. 80) U·g-1 ,respectively,significantly lower than (565. 07±22. 13) U·g-1 in the model control group (P<0. 05,P<0. 01). Histopathological analysis showed that degeneration and necrosis of hepatocytes were remarkably alleviated in all schisandra lignans treated groups. Conclusion Schisandra lignans protect rats against doxorubicin-induced liver injury.关键词
五味子木脂素/多柔比星/肝疾病Key words
Schisandra lignans/Doxorubicin/Liver diseases分类
医药卫生引用本文复制引用
安英,王艳春,徐路,范红艳,沈楠,赵丽晶,陈雪,徐博..五味子木脂素对多柔比星诱导肝损伤大鼠的保护作用[J].医药导报,2014,(9):1136-1139,4.基金项目
吉林省教育厅“十一五”科学技术研究基金资助项目(2009311) （2009311）
吉林省卫生厅科学技术研究基金资助项目(2012z060) （2012z060）
