医药导报Issue(10)：1310-1313,4.DOI:10.3870/yydb.2014.10.014
汉黄芩素对高脂血症小鼠的保护作用
Protection Effect of Wogonin on Mice with Hyperlipidemia
杨波 1周承志 1张道亮 1胡有志 1肖金凤1
作者信息
- 1. 湖北中医药大学附属医院、湖北省中医院心内科，武汉 430061
- 折叠
摘要
Abstract
Objective To explore the effects of wogonin on hyperlipidemia in mice and clarify the molecule mechanism. Methods Thirty mice were evenly divided into three group normal control group,model control group and treatment group. The normal control group was given normal diet,the model control group received high-fat diet,the treatment group received high-fat diet with wogonin (500 mg·kg-1 ). Results The mice developed hyperlipidemia 12 weeks after starting the high-fat diet. The body weight,visceral fat and fat index were increased (P<0. 05). After treatment,these indices were reduced ( P < 0. 01). Wogonin significantly reduced the total cholesterol ( TC),low density lipoprotein ( LDL),high density lipoprotein (HDL),except the triglyceride (TG). Compared to the model control group,the hepatic lipase(HL) and lipoprotein lipase(LPL) activity in the treatment group were recovered (P<0. 05),but HMG-CoA reductase activity was inhibited ( P<0. 01). Mechanistic study suggested that the lipid-lowering effect might be related to the lipid synthesis genes (SREBP-1c,FAS, PPARγ) and the lipid metabolism genes (PPARα,CPT-1). Conclusion Wogonin can prevent hyperlipidemia,which might be related to the regulation of enzyme activity and the changes of lipid synthesis and oxidative metabolism.关键词
汉黄芩素/高脂血症/氧化代谢/酶活性Key words
Wogonin/Dyslipidemia/Oxidative metabolism/Enzyme activity分类
医药卫生引用本文复制引用
杨波,周承志,张道亮,胡有志,肖金凤..汉黄芩素对高脂血症小鼠的保护作用[J].医药导报,2014,(10):1310-1313,4.
