医药导报Issue(10)：1365-1369,5.DOI:10.3870/yydb.2014.10.030
离子强度对甲氨蝶呤-树枝状大分子纳米粒稳定性的影响
Effect of Ionic Strength on Stability of Methotrexate-loaded Dendrimer Nanoparticles
摘要
Abstract
Objective To investigate the influence of ionic strength on the stability of the methotrexate-loaded dendrimer nanoparticles. Methods The influences of different ions (Na+,Cl-) and different concentrations of sodium chloride on the stability of the nanoparticles were studied. The particle size was measured by dynamic light scattering(DLS) and drug-loading content was determined by high-performance liquid chromatography (HPLC) in order to evaluate the stability. Results The Cl- was finally verified to play an important role in stabilizing the nanoparticles and the effective concentration of the sodium chloride was recommended to be below 1. 80% . Conclusion The recommended concentration (less than 1. 80% ) of the sodium chloride significantly improves the stability of the nanoparticles and benefits for long term storage.关键词
甲氨蝶呤/离子强度/粒径/纳米粒/稳定性Key words
Methotrexate/Ionic strength/Size/Nanoparticles/Stability分类
医药卫生引用本文复制引用
赵燕娜,杨力,郝春影,李艳红,王向涛,郭一飞..离子强度对甲氨蝶呤-树枝状大分子纳米粒稳定性的影响[J].医药导报,2014,(10):1365-1369,5.基金项目
国家自然科学基金资助项目(21004079) （21004079）
