医药导报Issue(11)：1438-1441,4.DOI:10.3870/yydb.2014.11.010
艾叶发酵物治疗系统性白念珠菌感染
Therapeutic Effects of Artemisia Argyi Ferment Substance on Systemic Candida Albicans Infection
摘要
Abstract
Objective To investigate the therapeutic effects and mechanism of Artemisia argyi ferment substance on systemic Candida albicans infection. Methods The model of systemic Candida albicans infection was established in immunosuppressed mice. The model mice were randomly divided into the model control,Artemisia argyi ferment substance( AAFS) at different doses(100,200,and 400 mg·kg-1 )and fluconazole group(20 mg·kg-1 ),30 mice in each. Mice in each treatment group were given therapeutic drugs by gavage for 5 consecutive days,twice daily. The survival of mice was determined 21 days after the model was set up. The serum levels of IFN-γand IL-2 were determined by ELISA. The proliferation activity of T lymphocyte in the spleen was detected by MTT assay. The number of living fungi in liver and kidney tissues was counted. Results Compared with the model control,AAFS at middle and high doses and fluconazole significantly increased the survival rate of mice,the serum levels of IFN-γand IL-2,and the proliferation activity of T lymphocyte in the spleen,but decreased the number of living fungi in tissues(P〈0. 01). Compared with low dose AAFS,middle and high doses of AAFS and fluconazole showed significantly different effect on each index(P〈0. 05 or P〈0. 01),but there was no difference among these groups(P〉0. 05). Conclusion AAFS at 200-400 mg·kg-1 has inhibitory effects on systemic Candida albicans infection in mice,the mechanism of which is related to increasing the proliferation of T lymphocyte in spleen and the levels of IFN-γand IL-2 in serum.关键词
艾叶发酵物/感染白念珠菌Key words
Artemisia argyi ferment substance/Infection,candida albicans分类
医药卫生引用本文复制引用
白静,胡雷,张丽,田春雨,庞得全,薄海美,韩淑英..艾叶发酵物治疗系统性白念珠菌感染[J].医药导报,2014,(11):1438-1441,4.基金项目
唐山市科技计划项目 （）
