医药导报Issue(4)：448-451,4.DOI:10.3870/yydb.2015.04.007
注射用华蟾素对大鼠心率及心电图的影响
Effect of Cinobufotalin Freeze-dry Powder on Heart Rate and Electrocardiograph of Anesthesia Rats
封郭生 1罗攀 2陈江伟 2朱莉 2甘露1
作者信息
- 1. 湖北省荆门市中医医院烧伤整形科，荆门 448000
- 2. 华中科技大学同济医学院药理学系，武汉 430030
- 折叠
摘要
Abstract
Objective To observe the effect of cinobufotalin freeze-dry powder on heart rate ( HR ) and electrocardiogram ( ECG) of SD rats and to provide experimental basis for monitoring its adverse effect on heart in clinical application. Methods The drug was administered into external jugular vein at constant speed throughout the whole experiment;standard-Ⅱ limb lead monitored the HR and ECG, and then the changes in HR and ECG before and after administration of cinobufotalin were compared. Results Thirty minutes after administration of cinobufotalin injection and cinobufotalin freeze-dry powder at middle dose and high dose, HR of the rats was significantly increased as compared with blank control group[(469±40) bpm, (466±29) bpm and (484±40) bpm vs. (411±17) bpm] (P<0. 05), but soon afterwards, it returned to normal. A small number of rats also developed arrhythmia. In addition, administration of cinobufotalin significantly shortened the P-R interval[blank control group: (46. 90±3. 90) ms, cinobufotalin injection administration group: (39. 70± 2. 54) ms;middle dose of cnobufotalin freeze-dry powder administration group: (37. 70±3. 77) ms; high dose of cinobufotalin freeze-dry powder administration group:(39. 30±7. 12) ms] and Q-T interval[blank control group:(61. 29±9. 46) ms;middle dose of cinobufotalin freeze-dry powder administration group: (55. 13±4. 67) ms; high dose of cinobufotalin freeze-dry powder administration group:(51.75±11. 53) ms] (P<0. 05), but QRS and S-T were unchanged (P>0. 05). Conclusion Cinobufotalin freeze-dry powder has some side effects on rat heart and can increase HR, even lead to arrhythmia.关键词
注射用华蟾素/心率/心律失常/心电图Key words
Cinobufotalin freeze-dry powder/Heart rate/Cavdiac rhythm/Electrocardiogram分类
医药卫生引用本文复制引用
封郭生,罗攀,陈江伟,朱莉,甘露..注射用华蟾素对大鼠心率及心电图的影响[J].医药导报,2015,(4):448-451,4.
