医药导报Issue(4)：459-463,5.DOI:10.3870/yydb.2015.04.010
注射用紫杉醇（清蛋白结合型）抗肿瘤作用
Antitumor Effect of Paclitaxel for Injection (Albumin Bound)
摘要
Abstract
Objective To compare the antitumor effect of self-developed albumin bound paclitaxel for injection ( PAB) and commercial albumin-bound paclitaxel for injection ( Abraxane ) . Methods The antineoplastic effects of PAB and Abraxane were evaluated in H22, Lewis and RM-1 allograft tumor mouse models after repeated intravenous injection (13. 4, 20. 0, 30. 0 and 45. 0 mg·kg-1 PAB and 20. 0 and/or 30. 0 mg·kg-1 Abraxane, respectively). Results PAB significantly inhibited H22 tumor growth at from the doses of 13. 4, 20. 0, 30. 0, and 45. 0 mg·kg-1,and the antitumor effect of PAB at 20. 0 mg·kg-1 was not significantly different from Abraxane at 20. 0 mg·kg-1 . PAB dose-dependently inhibited Lewis and RM-1 tumor growth at the doses of 20. 0, 30. 0, and 45. 0 mg·kg-1 . The no observed adverse effect level of PAB and Abraxane was 20. 0 mg· kg-1 in Lewis and RM-1 bearing C57 female mice. The antitumor effect and toxicity was not significantly different between PAB and Abraxane at equivalent doses. Conclusion At the same dose level, the antitumor activity and toxicity of PAB was equivalent to those of Abraxane.关键词
紫杉醇/清蛋白/抗肿瘤Key words
Paclitaxel/Albumin bound/Antitumor effect分类
医药卫生引用本文复制引用
王彩霞,高玉清,李艳玲,毕宇鑫,魏娜,赵倩,李春雷..注射用紫杉醇（清蛋白结合型）抗肿瘤作用[J].医药导报,2015,(4):459-463,5.基金项目
石家庄高端医药产业园区创新药物孵化基地课题任务(2011ZX09401-306) （2011ZX09401-306）
