医药导报Issue(5)：585-588,4.DOI:10.3870/yydb.2015.05.005
金叶败毒颗粒防治妊娠中期巨细胞病毒宫内感染的实验研究
Experimental Study of Prevention and Therapeutic Effect of Jinyebaidu Granules on Cytomegalovirus Infection During Mid-pregnancy
摘要
Abstract
Objective To study the effect of Jingyebaidu granules on treating cytomegalovirus ( CMV) infection during mid-pregnancy. Methods The sexually mature guinea pigs with no CMV infection history served as the subjects. Put the male and female ones in the same cages. Then the female ones were randomly divided into three groups during mid-pregnancy. Model control group:15 guinea pigs which were inoculated 1 mL suspension of GPCMV intraperitoneally. Jingyebaidu Medicine group:15 guinea pigs which were treated with Jingyebaidu(3. 09 mL·kg-1 ) through stomach perfusion after inoculation for 14 days. Normal control group:15 normal mid-pregnant guinea pigs. Viremia rates were examined 7 days after infection. All animals were sacrificed 20 days after infection. The placenta infection rate, pup infection rate, still-born rate were examined. Results Compared with the normal controls, the still-born rate was increased in model control group(8. 33% vs 34. 55%, P<0. 05). In comparison to the model control group, the GPCMV maternal infection rate(86. 67% vs 33. 33%), placenta infection rate (91. 67% vs 61. 22%), pup infection rate(90. 91% vs 48. 28%), still-born rate(34. 55% vs 15. 52%) were significantly decreased in the Jinyebaidu group (all P<0. 05). Conclusion Jinyebaidu granules could reduce maternal infection,pup loss, and placenta infection caused by CMV inoculation during mid-pregnancy.关键词
金叶败毒颗粒/巨细胞病毒/感染,宫内Key words
Jingyebaidu granules/Cytomegalovirus/Infection, intrauterine分类
医药卫生引用本文复制引用
李伟,陈素华,熊锦文,陈娟娟,刘涛,肖娟,刘静,张艳丽,冯云,曾雪..金叶败毒颗粒防治妊娠中期巨细胞病毒宫内感染的实验研究[J].医药导报,2015,(5):585-588,4.基金项目
国家自然科学基金资助项目(81200354) （81200354）
