摘要
Abstract
Objective To observe the efficacy of dexmedetomidine in simple orthopedic limb surgery with monitored anesthesia care (MAC).Methods 60 patients undergoing simple orthopedic limb surgery with MAC between 2013.07 and 2014.01 were selected and randomly divided into an observation group and a control group, with 30 cases in each group. Patients in observation group given 0.3μ g/Kg dexmedetomidine via intravenous infusion (duration 15 min), the maintenance dose is 0.3μ g/Kgoh.Patients in control group given continuous normal saline infusion until 10 minutes before surgery ended. The patients'MAP, HR, RR, SpO2,OAA/S score, dosage of local anesthetics, respiratory depression and intraoperative coordination were recorded before administration of dexmedetomidine (T0), 15 minutes after administration and time of sterilization (T1), administration of local anesthetic (T2) and start of surgery 30 min (T3), and at completion of surgery (T4).Results The observation group patients' MAP,SpO2 at T1, T2, T3 and T4 is not statistically significant (P>0.05) compared to T0, but HR was lower compared to T0, the control group patients' MAP,HR at T2,T3 were higher compared to T0,and SpO2 was lower than at T0,the difference is statistically significant (P<0.05).The observation group at time points from T1 to T4 had decreased OAA/S scores,and statistically significant compared to the control group (P<0.05). The difference between the observation group's and control group's local anesthetic dosage, incidence of respiratory depression and degree of patients'cooperation were also statistically significant (P<0.05).Conclusion Monitor status of patients under anesthesia during simple orthopedic limb surgery ,0.3μ g/Kg dexmedetomidine loading dose and 0.3μ g/Kg.h maintenance dose in patients resulted in discernable sedative effects, patients also showed stable hemodynamics,less stress reaction, no respiratory depression, were more easily woken up and oriented.increase patient compliance with surgery.This shows dexmedetomidine is safe to use as sedative in simple orthopedic limb surgery with MAC.关键词
右美托咪定/监测麻醉(MAC)/骨科肢体手术Key words
dexmedetomidine/monitored anesthesia care(MAC)/simple orthopedic limb surgery分类
医药卫生
