诊断学理论与实践Issue(4)：416-418,3.DOI:10.3969/j.issn.1671-2870.2014.04.015
老年轻度认知功能障碍IL-6、hs-CRP检测的临床意义
Clinical significance of serum IL-6, hs-CRP level in mild cognitive impairment of senior patients
摘要
Abstract
Objective: To investigate the correlations between interleukin-6 (IL-6), high sensitive C-reactive protein (hs-CPR) and mild cognitive impairment (MCI) in senior patients. Methods: One hundred senior patients suffering from mild cognitive impairment (MCI) were compared with 100 healthy senior controls. No significant differences were found in essential hypertension, diabetic mellitus, smoking, dyslipidemia, alcohol drinking, body mass index and teaching background between the two groups. Levels of serum IL-6 and hs-CRP were measured by enzyme-linked immunosorbent assay (ELISA) and immunoturbidimetry (ITM), respectively. Results:Compared with healthy control group, level of IL-6 in MCI patients was increased very significantly (P<0.01) and level of hs-CRP was increased significantly (P<0.05 ). Conclusions: MCI in elderly patients may be related to inflammatory course, serum IL-6 and hs-CRP as pro-inflammatory factors might play very important roles in MCI. Increased serum IL-6 probably is a sensitive marker for predicting MCI in elderly, and further studies are needed.关键词
轻度认知功能障碍/白细胞介素-6/超敏C反应蛋白Key words
Mild cognitive impairment (MCI)/Interleukin-6/High sensitive C-reactive protein分类
医药卫生引用本文复制引用
畅凌,郭恒,雷英,吴倩,张兰,黄刚..老年轻度认知功能障碍IL-6、hs-CRP检测的临床意义[J].诊断学理论与实践,2014,(4):416-418,3.基金项目
新疆生产建设兵团科学技术局资助（2012BA052) （）
