中国病理生理杂志Issue(4)：592-597,6.DOI:10.3969/j.issn.1000-4718.2014.04.003
内源性组胺减轻小鼠前脑缺血再灌注后期脑损伤
Effects of endogenous histamine on transient forebrain ischemia-induced neuronal damage at late phase of reperfusion in mice
摘要
Abstract
AIM: To determine the effect of endogenous histamine on transient forebrain ischemia-induced neuronal injury at the late phase of reperfusion using histidine decarboxylase knockout ( HDC-KO) mice.METHODS:Wild-type (WT) and HDC-KO mice were subjected to bilateral common carotid artery occlusion for 30 min followed by 3 d or 15 d of reperfusion.At different time points after reperfusion, the body weight, mortality rate, learning and memory in fear conditioning test and hippocampal CA 1 neuronal density were evaluated .RESULTS: At 1 d after reperfusion , the body weight loss was observed in both WT and HDC-KO mice.At 4 d, 5 d, 6 d and 7 d after reperfusion, the increment in the body weight of the HDC-KO mice was significantly smaller than that of the WT mice .During the period between 8 d and 14 d after reperfusion, the mortality rate of the HDC-KO mice was higher than that of the WT mice (P<0.05).At 14 d after reperfusion , the HDC-KO mice exhibited more aggravated deficits in contextual and cue memory compared with the WT mice.Correspondingly , a more severe CA1 neuronal injury in the HDC-KO mice than that in the WT mice was ob-served at 15 d but not at 3 d after reperfusion (P<0.05).CONCLUSION:Endogenous histamine may attenuate learn-ing/memory deficits and neuronal injury at the late phase of ischemia /reperfusion.However, the involved mechanisms need to be further investigated .关键词
前脑缺血/神经元损伤/内源性组胺Key words
Forebrain ischemia/Neuronal injury/Endogenous histamine分类
医药卫生引用本文复制引用
范彦英,马云鹏,乔圆,何萍,张轩萍,Hiroshi OHTSU,陈忠..内源性组胺减轻小鼠前脑缺血再灌注后期脑损伤[J].中国病理生理杂志,2014,(4):592-597,6.基金项目
国家自然科学基金资助项目（ No．81202520）；高等学校博士学科点专项科研基金资助项目（ No．20121417120002）；浙江省教育厅科研项目 （）
