中国病理生理杂志Issue(6)：1119-1122,4.DOI:10.3969/j.issn.1000-4718.2014.06.028
芪苈强心胶囊对冠心病合并心力衰竭患者血清脂联素水平及心功能的影响
Effects of Qili Qiangxin capsule on serum concentration of adiponectin and heart function in patients with coronary heart disease combined with congestive heart failure
李强 1郭壮波 1黎庆梅 2郭顺华3
作者信息
- 1. 暨南大学医学院第四附属医院，广州市红十字会医院 急诊科，广东广州510220
- 2. 暨南大学医学院第四附属医院，广州市红十字会医院 检验科，广东广州510220
- 3. 暨南大学医学院第四附属医院，广州市红十字会医院 超声诊断科，广东广州510220
- 折叠
摘要
Abstract
AIM:To investigate the effects of Qili Qiangxin capsule on serum adiponectin ( APN) , serum N-terminal pro-brain natriuretic peptide ( NT-proBNP) and heart function in the patients of coronary heart disease combined with congestive heart failure .METHODS: One hundred and twenty patients were randomly divided into treatment group and control group , and both groups were given anti-failure routine therapy .The patients in treatment group were treated with Qili Qiangxin capsule and the patients in control group were treated with placebo .The patients in the 2 groups were given a certain dose of the drugs for 6 months.The New York Heart Association (NYHA) heart function classification, left ventricular end-diastolic diameter (LVEDD), left ventricular end-systolic diameter (LVESD),left ventricular ejection frac-tion (LVEF), and 6-min walking test (6-MWT) were observed before and after treatment .The levels of APN, NT-proBNP were measured by ELISA before and after treatment .RESULTS:With the increase in the class of NYHA heart function , the serum concentrations of APN and NT-proBNP in the heart failure cases increased significantly .After 6-month treat-ment, the effective rate in experimental group was 91.7%and that in control group was 75.0%.A significant difference was found between the 2 groups (P<0.01).After treatment, LVEDD and LVESD in both groups were decreased signifi-cantly, and LVEF in both groups was increased significantly .The serum concentrations of APN and NT-proBNP decreased significantly (P<0.05).6-MWT result was improved significantly.Compared with control group, more obvious effect was observed in experimental group ( P<0.05) .CONCLUSION:Treatment with Qili Qiangxin capsule reduces the levels of APN and NT-proBNP in the patients with coronary heart disease combined with congestive heart failure .关键词
芪苈强心胶囊/冠心病/心力衰竭/脂联素/心功能Key words
Qili Qiangxin capsule/Coronary heart disease/Heart failure/Adiponectin/Cardiac function分类
医药卫生引用本文复制引用
李强,郭壮波,黎庆梅,郭顺华..芪苈强心胶囊对冠心病合并心力衰竭患者血清脂联素水平及心功能的影响[J].中国病理生理杂志,2014,(6):1119-1122,4.
