中国病理生理杂志Issue(7)：1214-1217,4.DOI:10.3969/j.issn.1000-4718.2014.07.011
野木瓜注射液对炎性疼痛小鼠背根神经节CO X-2表达的影响
Injection stauntoniae inhibits chronic inflammatory pain responses by changing COX-2 expression in carrageenan-inflamed mice
摘要
Abstract
AIM: To investigate the effect of injection stauntoniae ( IS) on inflammatory pain responses in mice.METHODS:The carrageenan test was used to determine the anti-inflammatory and analgesic effects of IS .Except for control group, the mice in other groups received an injection of λ-carrageenan solution (1%, 50 μL) into the plantar region of the left hind paws , followed by a subcutaneous injection of IS at doses of 12.5%, 50%and 100%or equal vol-ume of 0.9%NaCl.Both paw edema and hyperalgesia to thermal stimulation were measured 4 h, 12 h, 24 h and 48 h after the injection of λ-carrageenan solution.The lumbar-5 (L5) dorsal root ganglions (DRGs) of the mice were taken to inves-tigate the cyclooxygenase 2 ( COX-2) expression by immunohistochemical staining .RESULTS:Subcutaneous injection of IS potently inhibited paw edema and hyperalgesia induced by λ-carrageenan in the mice accompanied with the inhibition of COX-2 protein expression in L 5 DRGs.CONCLUSION:IS exerts the anti-inflammatory and analgesic effects on the in-flammatory responses by inhibiting the protein expression of COX-2 in DRGs.关键词
消炎/镇痛/野木瓜注射液/环氧化酶2/背根神经节Key words
Anti-inflammation/Analgesia/Injection stauntoniae/Cyclooxygenase 2/Dorsal root ganglion分类
医药卫生引用本文复制引用
杨燕京,李小军,刘力维,郭强,李玉桑,奉黎静,唐和斌..野木瓜注射液对炎性疼痛小鼠背根神经节CO X-2表达的影响[J].中国病理生理杂志,2014,(7):1214-1217,4.基金项目
国家自然科学基金资助项目（No．81101538）；教育部留学回国人员启动项目 （）
