中国病理生理杂志Issue(10)：1784-1788,5.DOI:10.3969/j.issn.1000-4718.2014.10.010
NF-κB 在糖尿病性神经痛中的作用及机制
Role of NF-κB in diabetic neuropathy
摘要
Abstract
AIM: To investigate the role of NF-κB in diabetic neuropathy.METHODS: The diabetic rats were induced by intraperitoneal injection of streptozocin ( STZ) .The pain behavior test was used to detect the mechanical and thermal withdraw threshold of the rats’ bilateral hind paws.The protein levels of p-NF-κB and t-NF-κB in the rats’ L4 and L5 dorsal root ganglions ( DRG) were determined by Western blotting.The expression of Nav1.7 in DRG of diabetic neuropathy rats with or without NF-κB inhibitor PDTC was detected by the method of immunohistochemistry.RESULTS:The mechanical and thermal withdraw threshold of bilateral hind paws in the diabetic rats was decreased from 4 weeks to 12 weeks after injection of STZ.The protein levels of p-NF-κB in L4 and L5 DRG were significantly increased in the rats with diabetic neuropathy.Intrathecal administration of NF-κB inhibitor PDTC attenuated the increase in p-NF-κB and Nav1.7 in L4 and L5 DRG.Pain behaviors were also alleviated by PDTC.CONCLUSION:The increase in p-NF-κB is closely rela-ted to the generation of diabetic neuropathy.Inhibition of NF-κB blocks pain behaviors and the over-expression of Nav1.7 in DRG.关键词
糖尿病性神经痛/NF-κB/电压门控性钠通道/背根神经节Key words
Diabetic neuropathy/NF-kappa B/Voltage-gated sodium channels/Dorsal root ganglion分类
医药卫生引用本文复制引用
黄阳亮,钟祎,胡景鑫..NF-κB 在糖尿病性神经痛中的作用及机制[J].中国病理生理杂志,2014,(10):1784-1788,5.基金项目
广东省自然科学基金博士启动基金资助项目 （）
