中国病理生理杂志Issue(10)：1891-1895,1901,6.DOI:10.3969/j.issn.1000-4718.2014.10.029
骨髓间充质干细胞联合维生素E对急性肾损伤炎症反应的抑制作用
Effect of bone marrow-derived mesenchymal stem cells combined with vi-tamin E on inflammatory reaction in acute kidney injury
摘要
Abstract
AIM: To explore the effect of bone marrow-derived mesenchymal stem cells (BMSCs) combined with vitamin E on the inflammatory reaction in acute kidney injury ( AKI) rats.METHODS:Gentamicin was used to in-duce AKI and the rats were treated with BMSCs combined with vitamin E.After treatment, the rat plasma and kidney tis-sues were collected, and the expression of inflammatory factors at mRNA and protein levels was detected by real-time quan-titative PCR and ELISA.RESULTS:After the treatment with BMSCs combined with vitamin E, the inflammatory proteins were down-regulated in the plasma and the renal tissues.Compared with single treatment group, the decreases in the in-flammatory proteins were more obvious in combined treatment group.CONCLUSION: The method of BMSCs combined with vitamin E takes the anti-inflammatory effect on AKI, indicating a new and potential mode in clinical application for AKI therapy.关键词
骨髓间充质干细胞/维生素E/急性肾损伤/炎症反应Key words
Bone marrow-derived mesenchymal stem cells/Vitamin E/Acute kidney injury/Inflammatory re-action分类
医药卫生引用本文复制引用
赵雷,冯业童,董超,周余来,刘朋飞..骨髓间充质干细胞联合维生素E对急性肾损伤炎症反应的抑制作用[J].中国病理生理杂志,2014,(10):1891-1895,1901,6.基金项目
深圳市知识创新计划（No．201404163000377）；吉林大学研究生创新基金资助项目 （）
