中国病理生理杂志Issue(12)：2272-2275,4.DOI:10.3969/j.issn.1000-4718.2014.12.028
Lgr5在慢性浅表性胃炎中的表达
Expression of Lgr5 in chronic superficial gastritis
摘要
Abstract
[ ABSTRACT] AIM: To investigate the expression and significance of Leucine-rich repeat-containing G-protein-coupled receptor 5 (Lgr5) in chronic superficial gastritis.METHODS:The Wistar rats (n=30) were randomly divided into blank group, model group and control group.The Wistar rat model of chronic superficial gastritis was established by in-tragastric administration of 0.02%ammonia and long-term irregular diet.All rats were sacrificed, and gastric tissues were harvested and stained with hematoxylin and eosin.The expression of Lgr5 at mRNA and protein levels was analyzed by re-verse transcriptional polymerase chain reaction, Western blotting and immunohistochemistry.RESULTS:Lgr5 was mainly expressed in the cell membrane and cytoplasm.Lgr5 showed high expression in model group compared with blank group and control group.No obvious difference between blank group and control group was observed.CONCLUSION:Persistent in-flammation leads to increased expression of Lgr5.Lgr5 may be a proinflammatory tumor promoting factor.关键词
Lgr5蛋白/Wnt信号通路/慢性浅表性胃炎Key words
Lgr5 protein/Wnt signaling pathway/Chronic superficial gastritis分类
医药卫生引用本文复制引用
周小嫔,王佐妤,刘彩红,谢立群..Lgr5在慢性浅表性胃炎中的表达[J].中国病理生理杂志,2014,(12):2272-2275,4.基金项目
武警后勤学院院级科学基金资助项目 （）
