中国病理生理杂志Issue(2)：201-206,6.DOI:10.3969/j.issn.1000-4718.2015.02.002
硫辛酸对 LPS 诱导的帕金森病小鼠黑质多巴胺能神经元损伤的影响
Lipoic acid protects dopaminergic neurons in LPS-induced model of Parkinson’s disease
摘要
Abstract
AIM:To evaluate the effect of lipoic acid ( LA) on LPS-induced Parkinson disease ( PD) model of mice.METHODS:Female C57BL/6 mice of 10-month-old were randomly divided into saline control group , PD group and LA group.The PD mouse model was induced by intranasal instillation of LPS .Assays of tyrosine hydroxylase , microglia and nuclear factor kappa B ( NF-κB) were performed by the methods of immunohistochemistry and Western blotting .RE-SULTS:Intranasal LPS instillation exhibited basic characteristics of PD model .However, LA administration significantly improved motor dysfunction , protected dopaminergic neurons from damage , and inhibited NF-κB activation in inflammatory microglia in the substantia nigra area of the brain .CONCLUSION:LA may exert a profound neuroprotective effect by an-ti-neuroinflammatory reaction to arrest the progression of PD .关键词
脂多糖/帕金森病/硫辛酸/小胶质细胞Key words
Lipopolysaccharide/Parkinson disease/Lipoic acid/Microglia分类
医药卫生引用本文复制引用
李艳花,马存根,和青,尉杰忠,刘春云,黄建军,丰玲,柴智,王青,肖保国..硫辛酸对 LPS 诱导的帕金森病小鼠黑质多巴胺能神经元损伤的影响[J].中国病理生理杂志,2015,(2):201-206,6.基金项目
国家自然科学基金资助项目（No．81272163）；山西省青年自然科学基金资助项目（No．2012021034－2）；山西大同大学博士科研启动经费（No．2011－B－11）；山西大同大学研究所科研项目启动经费；山西中医学院“2011”培育计划项目 （）
