中国病理生理杂志Issue(2)：219-223,5.DOI:10.3969/j.issn.1000-4718.2015.02.005
阿托伐他汀对脑缺血再灌注大鼠血脑屏障的保护作用
Protective effect of atorvastatin on blood brain barrier in rats with focal cerebral ischemia-reperfusion injury
摘要
Abstract
AIM:To explore the protective effects of atorvastatin on blood brain barrier (BBB) in cerebral is-chemia-reperfusion ( IR) injury and the potential mechanisms involved .METHODS: SD rats were divided into sham group, IR group and atorvastain group .Intraluminal suture method was used to establish cerebral IR model , and the ische-mic brain was reperfused for 72 h after the occlusion.The rats in atorvastatin group were administered with atorvastatin (20 mg・ kg-1・ d-1 ) by gavage once a day for 3 consecutive days after operation .At 72 h after reperfusion , neurological func-tion scores, the water content of the brain tissue , Evans blue (EB) content of ischemic hemisphere , the expression of tight junction ( TJ )-associated protein occludin and inflammation factor phosphatidylinositiol 3-kinase-p110 gamma ( PI3K-p110γ) were tested and analyzed .RESULTS: In IR group, the rats showed elevated neurological function scores ( P<0.01), brain tissue water content (P<0.01) and EB content (P<0.01), accompanied with the down-regulation of oc-cludin expression (P<0.01) and up-regulation of PI3K-p110γ(P<0.01) at 72 h after reperfusion.Compared with IR group, decreased brain edema (P<0.01) and EB leakage (P<0.01) were observed in atorvastatin group , accompanied with increased occludin expression (P<0.01) and decreased PI3K-p110γexpression (P<0.01).However, no statistical difference of the neurological function scores between the 2 groups was observed .CONCLUSION:Atorvastain attenuates cerebral IR injury , which may be associated with the inhibition of inflammatory reactions and the up -regulation of TJ-asso-ciated proteins to maintain the stability of BBB .关键词
脑缺血再灌注/阿托伐他汀/血脑屏障Key words
Cerebral ischemia-reperfusion/Atorvastatin/Blood brain barrier分类
医药卫生引用本文复制引用
贺涓涓,洪华,杨世亮..阿托伐他汀对脑缺血再灌注大鼠血脑屏障的保护作用[J].中国病理生理杂志,2015,(2):219-223,5.基金项目
国家自然科学基金资助项目（No．30971028）；广东省自然科学基金资助项目 （）
