中国病理生理杂志Issue(4)：630-634,5.DOI:10.3969/j.issn.1000-4718.2015.04.010
Am80通过促进 KLF4与维甲酸受体α相互作用抑制血管内膜增生
Am80 inhibits neointima hyperplasia by promoting interaction of KLF4 with RARα
摘要
Abstract
[ ABSTRACT] AIM:To investigate the inhibitory effect of Am80 on neointima hyperplasia in carotid arteries after balloon injury and to observe the interaction between Krüppel-like factor 4 (KLF4) and retinoic acid receptorα(RARα). METHODS:Neointima hyperplasia in carotid arteries was observed by hemotoxylin and eosin staining.The expression of KLF4 and cyclin D1 was examined by immunostaining and Western blotting analysis.To detect the interaction between KLF4 and RARαin the vascular tissue, the injured arteries were harvested, and the protein extracts were prepared and subjected to co-immunoprecipitation assay.RESULTS:Compared with injured group, Am80 significantly reduced neointi-mal hyperplasia and the thickness ratio of intima to media.Am80 not only up-regulated KLF4 or RARαexpression in caro-tid arteries, but also increased the interaction between KLF4 and RARαat tissue levels.CONCLUSION:Am80 inhibits neointima hyperplasia in carotid arteries after balloon injury by promoting the interaction between KLF4 and RARα.关键词
Am80/Krüppel样因子4/维甲酸受体α/内膜增生Key words
Am80/Krüppel-like factor 4/Retinoic acid receptor α/Neointima hyperplasia分类
医药卫生引用本文复制引用
吕心瑞,徐晓,陈明亮,贾建新,王保芳,刘建林..Am80通过促进 KLF4与维甲酸受体α相互作用抑制血管内膜增生[J].中国病理生理杂志,2015,(4):630-634,5.基金项目
国家自然科学基金资助项目（No．U1404310）；河南大学博士启动基金 （）
