中国病理生理杂志Issue(4)：759-763,5.DOI:10.3969/j.issn.1000-4718.2015.04.033
LRP-1调控血管完整性的研究进展
Advances in LRP-1-regulated vascular integrity
摘要
Abstract
Low-density lipoprotein receptor-related protein-1 (LRP-1) is a transmembrane receptor protein locatedon the plasma membrane of the cells and involved in receptor-mediated endocytosis.LRP-1 binds to distinct ligandsthat are structurally and functionally unrelated, which makes it not only mediates endocytosis, but also regulates cell surfaceproteolytic activity and specific intracellular signaling pathways related to multiple links in the process of developmentof atherosclerosis.Moreover, LRP-1 plays an important role in maintaining vascular stability.This review focuses on theprogress in LRP-1-regulated vascular integrity, and provides new insights to the target of the blood vessel diseases.关键词
低密度脂蛋白相关受体1/凝血因子Ⅷ/胞吞/信号通路Key words
Low-density lipoprotein receptor-related protein-1/Goàgulàtion factor Ⅷ/Endocytosis/Signalpathway分类
医药卫生引用本文复制引用
杨燕,吴剑波..LRP-1调控血管完整性的研究进展[J].中国病理生理杂志,2015,(4):759-763,5.基金项目
国家自然科学基金资助项目（No．81172050）；四川省科技厅资助项目 （）
