中国病理生理杂志Issue(5)：947-949,955,4.DOI:10.3969/j.issn.1000-4718.2015.05.032
pEZRThr567在肺鳞癌中的表达及临床病理学意义
Clinicopathological significance of pEZRThr567 expression in lung squamous carcinoma
摘要
Abstract
AIM:To investigate the clinicopathological significance of the protein expression of phosphorylated ezrin at threonine 567 ( pEZRThr567 ) in lung squamous cell carcinoma, adjacent tissues and normal tissues.METHODS:pEZRThr567 protein was detected in lung squamous carcinoma, adjacent and normal tissues by the method of immunohisto-chemistry.The correlation of pEZRThr567 expression with clinicopathological parameters of lung squamous carcinomas was al-so analyzed.The localization of pEZRThr567 was detected by immunofluorescence staining in lung squamous cell line EBC-1. RESULTS:The protein expression of pEZRThr567 in lung squamous carcinoma was significantly higher than that in the adja-cent and normal lung tissues (P<0.01).pEZRThr567 mainly localized on the cell membrane, and its over-expression signi-ficantly correlated with the differentiation, clinical stage and lymph node metastasis in lung squamous carcinoma.CON-CLUSION:pEZRThr567 may be an effective biomarker for prediction of malignant potential and poor prognosis of lung cancer.关键词
肺鳞癌/埃兹蛋白/免疫组织化学Key words
Lung squamous carcinoma/Ezrin/Immunohistochemistry分类
医药卫生引用本文复制引用
张源,金承龙,王申桐,杨洋,林贞花,金铁峰..pEZRThr567在肺鳞癌中的表达及临床病理学意义[J].中国病理生理杂志,2015,(5):947-949,955,4.基金项目
国家自然科学基金资助项目 （）
