中国病理生理杂志Issue(6)：1008-1013,6.DOI:10.3969/j.issn.1000-4718.2015.06.008
加减一阴煎改善去势大鼠内皮功能紊乱
Effect of Jia-jian-yi-yin decoction on endothelial dysfunction in ovariecto-mized female rats
摘要
Abstract
[ ABSTRACT] AIM:To investigate the effect of Jia-jian-yi-yin decoction on endothelium-dysfunction in ovariecto-mized rats.METHODS:The ovariectomized rats were treated with Jia-jian-yi-yin decoction or turbid liquid of estradiol va-lerate for 8 weeks.The vascular ring tension was measured.Scanning electron microscopy and Western blotting were ap-plied to assess the function of endothelium-dependent dilation, aortic endothelial morphology and the expression of endothe-lial lipase.The pathologic sections were prepared to observe the effect of Jia-jian-yi-yin decoction on the uterus.RE-SULTS:In ovariectomized rats, the decrease in endothelium-dependent relaxation to acetylcholine ( ACh) was reversed to normal level, the endothelial morphology returned to normal without lipid accumulation and the endothelial lipase expression was decreased by Jia-jian-yi-yin decoction.Furthermore, no obvious change of the wet weight of uterine between the ovari-ectomized rats with or without Jia-jian-yi-yin decoction treatment was observed.CONCLUSION:Jia-jian-yi-yin decoction may have protective effects on endothelium-dependent vasodilation and aortic endothelial morphology in estrogen-deficient animals.关键词
加减一阴煎/戊酸雌二醇/内皮依赖性舒张/内皮脂肪酶Key words
KEY WORDS] Jia-jian-yi-yin decoction/Estradiol valerate/Endothelium-dependent dilation/Endothelial lipase分类
医药卫生引用本文复制引用
徐静婷,曹娅麟,郑文晖,张亚星,王玲,王庭槐..加减一阴煎改善去势大鼠内皮功能紊乱[J].中国病理生理杂志,2015,(6):1008-1013,6.基金项目
国家自然科学基金资助项目（No．81172525）；广东省科技厅项目 （）
