中国病理生理杂志Issue(7)：1294-1299,6.DOI:10.3969/j.issn.1000-4718.2015.07.025
脂多糖结合蛋白在脓毒症患者诊断和预后预测中的作用
Measurement of serum lipopolysaccharide binding protein for diagnosis and prognosis prediction in septic patients
焦京 1蒋宇 2高敏 3王念 2杨明施 3肖献忠2
作者信息
- 1. 湖南师范大学医学院生物化学与分子生物学教研室，湖南长沙410006
- 2. 中南大学 湘雅医学院病理生理学教研室，湖南长沙410013
- 3. 中南大学 湘雅三医院急危重症医学中心，湖南长沙410013
- 折叠
摘要
Abstract
AIM:To investigate the role of lipopolysaccharide binding protein (LBP) for diagnosis and prog-nosis prediction in the septic patients.METHODS:A total number of 80 ICU patients were enrolled.The patients were divided into systemic inflammatory response syndrome ( SIRS) group and sepsis group, the patients in sepsis group were di-vided into non-survivor sub-group and survivor sub-group.We collected the serum samples and analyzed acute physiology and chronic health evaluation ( APACHE) II score on the first day of the patients hospitalized in ICU.In addition, we also selected 10 healthy volunteers and collected their serum samples.The serum concentrations of LBP, C-reactive protein ( CRP) and procalcitonin ( PCT) were measured by ELISA.ROC analysis of LBP, CRP, PCT and APACHE II score was conducted to discriminate among critically ill patients with sepsis and predict the prognosis of the patients with sepsis.RE-SULTS:The levels of the 4 indicators in the septic patients were higher than those in the patients of SIRS (P<0.05).In addition, serum LBP and APACHE II score in the non-survivor sub-group were higher than those in the survivor sub-group (P<0.05), whereas no difference of the PCT and CRP levels between survivors and non-survivors with sepsis was ob-served.LBP levels greater than 26.84 mg/L had 97.1% sensitivity and 95.9% specificity to discriminate between SIRS and sepsis.LBP levels greater than 54.16 mg/L had 85.2%sensitivity and 80.0%specificity for prognosis of unfavorable outcome.CONCLUSION:LBP level was more accurately correlated with diagnosis or prognosis prediction than CRP or PCT in patients with sepsis.关键词
脓毒症/脂多糖结合蛋白/APACHEⅡ评分/C反应蛋白/降钙素原Key words
Sepsis/Lipopolysaccharide binding protein/APACHE II score/C-reactive protein/Procalcitonin分类
医药卫生引用本文复制引用
焦京,蒋宇,高敏,王念,杨明施,肖献忠..脂多糖结合蛋白在脓毒症患者诊断和预后预测中的作用[J].中国病理生理杂志,2015,(7):1294-1299,6.
