中国当代儿科杂志Issue(10)：984-987,4.DOI:10.7499/j.issn.1008-8830.2014.10.005
不同剂量万古霉素治疗儿童金黄色葡萄球菌肺炎的血药浓度分析
Analysis of serum vancomycin concentration after administration of different doses in children with Staphylococcus aureus pneumonia
摘要
Abstract
Objective To analyze serum vancomycin concentration after administration of different therapeutic doses in children with Staphylococcus aureus pneumonia (SAP) in order to determine the appropriate dose of vancomycin in clinical administration. Methods The clinical data of 35 children who were diagnosed with SAP and treated with vancomycin from January 2008 to December 2013 were retrospectively analyzed. Results Among the 35 SAP cases with vancomycin therapy, 22 cases (63%) had serum vancomycin trough concentration monitored. The numbers of cases with vancomycin at 10, 12.5, and 15 mg/(kg·dose) × every 6 hours (q6h) were 11, 4 and 7, respectively. The mean serum trough concentration of vancomycin in the 15 mg/(kg·dose) group was 14.98 mg/L, which was signiifcantly higher than in the 10 mg/(kg·dose) and 12.5 mg/(kg·dose) groups (4.97 and 8.00 mg/L respectively;P<0.05). The percentage of cases that reached the expected trough concentration in the 15 mg/(kg·dose) group (71%) was significantly higher than that in the 10 mg/(kg·dose) group (9%), but there was no significant difference in this percentage between the 15 mg/(kg·dose) and 12.5 mg/(kg·dose) groups (71%vs 25%). Conclusions The reasonable dosage of vancomycin for the treatment of pediatric SAP is 15 mg/(kg·dose) × q6h or 60 mg/(kg·d).关键词
万古霉素/肺炎/金黄色葡萄球菌/儿童Key words
Vancomycin/Pneumonia/Staphylococcus aureus/Child引用本文复制引用
张光莉,张慧,刘茹,张思颖,李俊奇,李颖,张东伟,罗征秀..不同剂量万古霉素治疗儿童金黄色葡萄球菌肺炎的血药浓度分析[J].中国当代儿科杂志,2014,(10):984-987,4.基金项目
国家临床重点专科建设项目（2011-873）资助。 （）
