中国当代儿科杂志Issue(10)：988-992,5.DOI:10.7499/j.issn.1008-8830.2014.10.006
上呼吸道感染儿童鼻咽部携带肺炎链球菌状况及血清型和耐药性研究
Nasopharyngeal carriage rate, antimicrobial resistance and serotype distribution of Streptococcus pneumoniae among children with upper respiratory infection
摘要
Abstract
Objective To investigate nasopharyngeal carriage rate, antimicrobial resistance and serotype distribution of Streptococcus pneumoniae among children with upper respiratory infection. Methods Nasopharygeal swabs were collected from children with upper respiratory infection visiting the outpatient department of Beijing Children's Hospital between March 2013 and February 2014. The antibiotic susceptibility was tested by Etest method, and the serotype was determined by Quellung reaction. Results The nasopharyngeal carriage rate for Streptococcus pneumoniae was 23.8%(699/2 941). One hundred isolates were randomly chosen for antimicrobial susceptiblity test and serotyping. Up to 98.0%isolates were susceptible to parenteral penicillin. The susceptible rate against oral penicillin, however, was 33.0%. The non-susceptible rate to erythromycin and azithromycin was 97.0%. The multi-drug resistance rate was up to 86.0%. The common serotypes were 6A(12.0%), 19F(12.0%), 6B(10.0%), 23F(9.0%) and 14(8.0%). The coverage rates of 7-, 10-and 13-valent pneumococcal conjugate vaccine were 41.0%, 42.0%and 59.0%respectively. Conclusions About 25%of children with upper respiratory infection are nasopharyngeal colonized by Streptococcus pneumoniae. The isolates show a high antimicrobial resistance. The 13-valent pneumococcal conjugate vaccine covers about 60.0%of the isolates.关键词
肺炎链球菌/携带率/抗生素耐药/血清分型/儿童Key words
Streptococcus pneumoniae/Carriage rate/Antimicrobial resistance/Serotype/Child引用本文复制引用
俞桑洁,高薇,史伟,袁林,申阿东,姚开虎,杨永弘..上呼吸道感染儿童鼻咽部携带肺炎链球菌状况及血清型和耐药性研究[J].中国当代儿科杂志,2014,(10):988-992,5.基金项目
首都卫生发展科研专项项目重点攻关（项目编号首发2011-2009-05），北京市科委行业定额经费自主项目（2014-bjsekyjs-3）。 （）
