中国当代儿科杂志Issue(10)：1014-1018,5.DOI:10.7499/j.issn.1008-8830.2014.10.011
早产儿支气管肺发育不良严重程度的影响因素
Inlfuencing factors for severity of bronchopulmonary dysplasia in preterm infants
摘要
Abstract
Objective To explore the inlfuencing factors for the severity of bronchopulmonary dysplasia (BPD) in preterm infants. Methods The clinical data of 110 preterm infants who were diagnosed with BPD and had a hospital stay of over 28 days between January 2011 and December 2013 were analyzed. These BPD infants were divided into 3 groups according to the clinical criteria:mild group (n=52), moderate group (n=44), and severe group (n=14). The relationship between the severity of BPD and the gestational age, birth weight, asphyxia, oxygen therapy, pregnancy complications, intrauterine pneumonia and mechanical ventilation was analyzed. Results The severity of BPD was correlated with the following factors:gestational age, birth weight, prenatal infection, duration of oxygen inhalation with a concentration of>40%, use of mechanical ventilation, parameters and duration of mechanical ventilation, duration of continuous positive airway pressure, adoption of intubation surfactant extubation (INSURE) approach, Ureaplasma urealyticum infection, intrauterine pneumonia and patent ductus arteriosus. Logistic regression analysis indicated that the mechanical ventilator parameter peak inspiratory pressure (OR=1.260, 95%CI:1.096-1.448) and duration of mechanical ventilation (OR=1.010, 95%CI:1.005-1.016) were independent risk factors for the severity of BPD, while the INSURE approach was a protective factor (OR=0.208, 95%CI:0.060-0.923). Conclusions The severity of BPD is associated with various factors in preterm infants. The important measures for preventing BPD include avoiding the birth of preterm infants with a very low birth weight, shortening the duration of mechanical ventilation, preventing and reducing pulmonary infections, and applying the INSURE approach.关键词
支气管肺发育不良/危险因素/早产儿Key words
Bronchopulmonary dysplasia/Risk factor/Preterm infant引用本文复制引用
李燕,韦秋芬,潘新年,蒙丹华,韦玮,伍秋频..早产儿支气管肺发育不良严重程度的影响因素[J].中国当代儿科杂志,2014,(10):1014-1018,5.基金项目
广西壮族自治区卫生厅自筹课题（Z2012214）；广西壮族自治区卫生厅重点课题（重2012022）。 （）
