中国当代儿科杂志Issue(10)：1019-1024,6.DOI:10.7499/j.issn.1008-8830.2014.10.012
CAMSBDH-ALL方案治疗儿童急性淋巴细胞白血病的中长期疗效观察
Long-term efifcacy of CAMSBDH-ALL chemotherapy protocol for the treatment of childhood acute lymphoblastic leukemia
摘要
Abstract
Objective To study the long-term efficacy of CAMSBDH-ALL chemotherapy protocol for the treatment of childhood acute lymphoblastic leukemia (ALL). Methods Three hundred and eighteen children who were newly diagnosed with ALL between January 1999 and December 2007 were enrolled in this study. Among the 318 children, 83 children who hospitalized before December 2002 were treated with CAMSBDH-ALL99 protocol, including 48 patients of standard risk and 35 patients of high risk. The patients (n=235;131 in standard risk and 104 in high risk) who hospitalized after December 2002 were treated with CAMSBDH-ALL03 protocol. Patients in the CAMSBDH-ALL99 protocol group were treated with conventional chemotherapy. CAMSBDH-ALL03 protocol was modiifed based on the CAMSBDH-ALL99 protocol. Results The long-term overall survival (OS) and event-free-survival (EFS) in the CAMSBDH-ALL03 group was signiifcantly higher than in the CAMSBDH-ALL99 (P<0.01). The long-term OS and EFS of standard risk and high risk patients in the CAMSBDH-ALL03 protocol group were signiifcantly higher than in the CAMSBDH-ALL99 protocol group (P<0.01). The CAMSBDH-ALL03 protocol group showed a significantly lower recurrence rate (28.9%) than in the CAMSBDH-ALL99 protocol group (50.6%) (P<0.05). The mortality rate in the CAMSBDH-ALL03 protocol group was 28.5%vs 56.6%in the CAMSBDH-ALL99 protocol group (P<0.05). Conclusions The therapeutic effect of the CAMSBDH-ALL03 protocol is supior to the CAMSBDH-ALL99 protocol group for childhood ALL, with a higher long-term survival rate. [Chin J Contemp Pediatr, 2014, 16(10):1019-1024]关键词
急性淋巴细胞白血病/化疗/儿童Key words
Acute lymphoblastic leukemia/Chemotherapy/Child引用本文复制引用
陈晓娟,刘芳,刘天峰,张家源,戚本泉,常丽贤,竺晓凡,邹尧,陈玉梅,杨文钰,王书春,郭晔,张丽,阮敏,刘晓明..CAMSBDH-ALL方案治疗儿童急性淋巴细胞白血病的中长期疗效观察[J].中国当代儿科杂志,2014,(10):1019-1024,6.基金项目
天津市科技支撑计划（12ZCDZSY18100）。 （）
