摘要
Abstract
Objective To investigate the correlation between four serum ifbrosis markers and liver function in patients with infantile hepatitis syndrome (IHS), and to explore the clinical signiifcance of these markers in the diagnosis of IHS and the assessment of disease severity. Methods A retrospective study was performed on 60 patients with IHS who were divided into hepatic ifbrosis and normal groups based on ultrasound diagnosis. Levels of four liver ifbrosis markers, i.e., hyaluronic acid (HA), type III procollagen (PC-III), type IV collagen (IV.C), and laminin (LN), were compared between the two groups, and the correlation between these markers and liver function was analyzed. Results Levels of liver function markers (alanine aminotransferase (ALT), glutamyl transpeptidase (GGT), total bilirubin (TBil), direct bilirubin (DBil), indirect bilirubin (IBil), and total bile acid (TBA)) in the hepatic ifbrosis group were signiifcantly higher than those in the normal group (P<0.05). Levels of HA and IV.C in the hepatic ifbrosis group were signiifcantly higher compared with those in the normal group (P<0.05). Furthermore, HA, IV.C, and PC-III levels were positively correlated with those of ALT, TBil, GGT, DBil, IBil, and TBA (r=0.25-0.49), and the strongest correlation existed between HA/IV.C and ALT/jaundice markers. Conclusions Assay measuring serum ifbrosis markers (HA, IV.C, and PC-III) in combination with liver function tests and ultrasound examination has an important clinical value in the early diagnosis of IHS and evaluation of disease severity.关键词
婴儿肝炎综合征/肝纤维化指标/肝功能检查/儿童Key words
Infantile hepatitis syndrome/Serum ifbrosis marker/Liver function test/Child
