中国当代儿科杂志Issue(10)：1070-1074,5.DOI:10.7499/j.issn.1008-8830.2014.10.024
小分子RNA在先天性心脏病中的研究进展
Research advances on role of microRNAs in congenital heart diseases
摘要
Abstract
MicroRNAs (miRNAs) are a class of small non-coding RNAs, which mainly regulate gene expression through post-transcriptional process. They are highly conserved, tissue-speciifc and highly speciifc in miRNA-binding on 3’-untranslated regions. MicroRNAs have been identified as crucial regulators in myocardial cell proliferation, differentiation and apoptosis, migration of cardiac neural crest cells, cardiac morphogenesis and cardiac patterning processes, which may provide a new insight into the research on developmental mechanism of congenital heart diseases. The research on miRNAs in congenital heart diseases includes clinical research and animal experiments. This article reviews two types of research advances, the mechanism of congenital heart diseases, and the current status and limitation of the domestic reports.关键词
小分子RNA/先天性心脏病/心脏发育Key words
MicroRNAs/Congenital heart disease/Cardiac development引用本文复制引用
严华林(综述),华益民(审校)..小分子RNA在先天性心脏病中的研究进展[J].中国当代儿科杂志,2014,(10):1070-1074,5.基金项目
国家自然科学基金（81070136、81270226）。 （）
