中国当代儿科杂志Issue(11)：1129-1132,4.DOI:10.7499/j.issn.1008-8830.2014.11.012
枸橼酸咖啡因与氨茶碱治疗早产儿原发性呼吸暂停的比较
Comparison of caffeine citrate and aminophylline for treating primary apnea in premature infants
许景林 1王瑞泉 1陈冬梅1
作者信息
- 1. 福建省泉州市儿童医院新生儿科，福建泉州 362000
- 折叠
摘要
Abstract
Objective To investigate the clinical efifcacy and safety of caffeine citrate and aminophylline in the treatment of primary apnea in premature infants. Methods The clinical data of 125 premature infants with primary apnea from March 2013 to March 2014 were retrospectively analyzed. According to the therapeutic strategy, the patients were divided into caffeine citrate group (n=65) and aminophylline group (n=60). The overall response rates and adverse reaction rates in the two groups were compared. Results The overall response rate in the caffeine citrate group was 86% (56 cases), which was significantly higher than that in the aminophylline group (72%, 43 cases) (P<0.05). The adverse reactions in the caffeine citrate group included tachycardia (1 case), restlessness (5 cases), feeding intolerance (7 cases), electrolyte disturbance (2 cases), and high blood glucose (5 cases), the incidence of which was signiifcantly lower than that in the aminophylline group (P<0.05). Conclusions Caffeine citrate is more effective and causes fewer adverse reactions than aminophylline in the treatment of primary apnea in premature infants.关键词
枸橼酸咖啡因/氨茶碱/原发性呼吸暂停/早产儿Key words
Caffeine citrate/Aminophylline/Primary apnea/Premature infant引用本文复制引用
许景林,王瑞泉,陈冬梅..枸橼酸咖啡因与氨茶碱治疗早产儿原发性呼吸暂停的比较[J].中国当代儿科杂志,2014,(11):1129-1132,4.
