中国当代儿科杂志Issue(12)：1211-1214,4.DOI:10.7499/j.issn.1008-8830.2014.12.005
CD4+CD25+Foxp3+调节性T细胞与IL-33在儿童哮喘发病机制中的作用
Roles of CD4+CD25+Foxp3+ regulatory T cells and IL-33 in the pathogenesis of asthma in children
潘珍珍 1李羚 1郭赟 1贺建1
作者信息
- 1. 南京医科大学附属无锡市儿童医院呼吸内科，江苏 无锡 214000
- 折叠
摘要
Abstract
ObjectiveTo study the roles of CD4+CD25+Foxp3+ regulatory T cells (Treg) and IL-33 in the pathogenesis of asthma in children.MethodsFlow cytometry was used to detect peripheral blood CD4+CD25+Foxp3+Treg proportion in CD4+T lymphocytes in.45 children with asthma, 50 children with wheezing caused by respiratory syncytial virus infection and 40 healthy children. Serum levels of IFN-γ, IL-4, IL-5 and IL-33 were measured using ELISA.ResultsThe level of peripheral blood CD4+CD25+Foxp3+Treg in the asthma group was significantly lower than in the wheezing and control groups (P<0.05). In contrast, serum levels of IL-33 in the asthma group was signiifcantly higher than in the wheezing and control groups (P<0.05). Peripheral blood CD4+CD25+Foxp3+Treg level was negatively correlated with serum IL-33 level in the asthma group(r=-0.156,P<0.01). ConclusionsCD4+CD25+Foxp3+Treg may interact with IL-33 in the pathogenesis of childhood asthma.关键词
CD4+CD25+Foxp3+调节性T细胞/IL-33/哮喘/儿童Key words
CD4+CD25+Foxp3+ regulatory T cell/IL-33/Asthma/Child引用本文复制引用
潘珍珍,李羚,郭赟,贺建..CD4+CD25+Foxp3+调节性T细胞与IL-33在儿童哮喘发病机制中的作用[J].中国当代儿科杂志,2014,(12):1211-1214,4.
