中国当代儿科杂志Issue(2)：128-133,6.DOI:10.7499/j.issn.1008-8830.2015.02.004
血氧饱和度对超早早产儿预后影响的Meta分析
What is the optimal oxygen saturation for extremely premature infants? A Meta analysis
李井洋 1林振浪 1魏佳 1颜艳燕 1林锦1
作者信息
- 1. 温州医科大学附属第二医院/育英儿童医院新生儿科，浙江温州 325027
- 折叠
摘要
Abstract
Objective To explore an optimal oxygen saturation for extremely preterm infants based on a systemic review of the published studies. Methods A Meta analysis of the published studies by the NeOProM Group which compared the outcomes of extremely preterm infants (gestational age<28 weeks) maintained in either a low (85%-89%) or high (91%-95%) oxygen saturation (SpO2) by using the STATA 12.0. The outcomes measured included the mortality and the incidences of retinopathy of prematurity (ROP), necrotizing enterocolitis of newborn (NEC), broncho-pulmonary dysplasia (BPD), intraventricular hemorrhage (IVH) and patent ductus arteriosus (PDA). Results Three studies were included, in which 2 460 infants were assigned into the low SpO2 group and 2 459 infants in the high SpO2 group. The Meta analysis demonstrated that the risk of mortality before discharge or at the age of 18 months increased in the low SpO2 group compared with the high SpO2 group (RR:1.19;95%CI:1.05-1.35);the risk of ROP decreased in the low SpO2 group (RR:0.73;95%CI:0.53-1.00);the risk of NEC increased in the low SpO2 group (RR:1.26;95%CI:1.06-1.49). There was no signiifcance in the incidences of BPD, IVH and PDA between the two groups. Conclusions Maintaining SpO2 at 85%-89% may decrease the incidence of ROP, but increase the mortality rate and the incidence of NEC in extremely premature infants.关键词
血氧饱和度/Meta分析/预后/超早早产儿Key words
Oxygen saturation/Meta analysis/Outcome/Extremely preterm infant引用本文复制引用
李井洋,林振浪,魏佳,颜艳燕,林锦..血氧饱和度对超早早产儿预后影响的Meta分析[J].中国当代儿科杂志,2015,(2):128-133,6.
