中国当代儿科杂志Issue(4)：303-307,5.DOI:10.7499/j.issn.1008-8830.2015.04.002
儿童侵袭性与非侵袭性肺炎链球菌耐药性的对照研究
Control study on antimicrobial resistance of invasive and non-invasiveStreptococcus pneumoniae in children
歹丽红 1董琳 1李海燕 1苏苗赏1
作者信息
- 1. 温州医科大学附属育英儿童医院呼吸科，浙江 温州 325027
- 折叠
摘要
Abstract
ObjectiveTo investigate the antimicrobial resistance of invasive and non-invasiveStreptococcus pneumoniae (SP) strains in children and to provide a basis for proper use of antimicrobial drugs in the treatment of SP infection.MethodsSeventy children who were diagnosed with invasive pneumococcal diseases (IPD) between January 2009 and December 2013 were enrolled, and 164 children with lower respiratory tract infection caused by SP were randomly selected as the control group. The samples from sterile sites (blood, cerebrospinal lfuid, etc) of children with IPD, as well as the sputum samples of children in the control group, were collected for bacterial culture, and the drug susceptibility tests for isolated SP strains were conducted.ResultsA total of 82 invasive strains of SP were isolated from sterile sites of 70 children with IPD; 49 strains (60%) were isolated from blood, and 19 strains (23%) from cerebrospinal lfuid. The detection rate of invasive SP strains decreased from 2009 to 2013 (P<0.01). The total detection rates of penicillin-nonsusceptible SP from the invasive and non-invasive strains were 27% and 17% respectively (P>0.05). Among invasive strains, the penicillin-nonsusceptible SP strains had significantly higher rates of insusceptibility to cefotaxime, ceftriaxone, and cefepime than the penicillin-susceptible SP (P<0.01). There were signiifcant differences in the rates of insusceptibility to cefotaxime, ceftriaxone, and meropenem between the sensitive and non-sensitive SP strains (P<0.05). The multidrug resistance rates of the invasive and non-invasive SP strains were 89% and 93%respectively (P>0.05).ConclusionsInvasive SP can easily invade the blood in children, but the total detection rate has decreased year by year. The results of drug sensitivity tests have guiding signiifcance for proper use of antimicrobial drugs for different SP infections.关键词
肺炎链球菌感染/药物耐药/细菌/儿童Key words
Streptococcus pneumoniaeinfection/Drug resistance/Bacterium/Child引用本文复制引用
歹丽红,董琳,李海燕,苏苗赏..儿童侵袭性与非侵袭性肺炎链球菌耐药性的对照研究[J].中国当代儿科杂志,2015,(4):303-307,5.
