中国当代儿科杂志Issue(4)：317-320,4.DOI:10.7499/j.issn.1008-8830.2015.04.005
1~3岁哮喘患儿呼出气一氧化氮水平与外周血嗜酸性粒细胞计数及肺功能的相关性
Correlation of fractional exhaled nitric oxide with peripheral blood eosinophils and lung function in 1-3-year-old children with asthma
摘要
Abstract
ObjectiveTo examine fractional exhaled nitric oxide (FeNO) values in 1-3-year-old children with asthma and analyze the correlation of FeNO with peripheral blood eosinophils (EOS) and lung function in these children.MethodsA total of 111 children aged 1-3 years with asthma were enrolled. The children were classiifed into acute exacerbation (n=62) and remission groups (n=49) according to their symptoms. FeNO values, lung function, and peripheral blood EOS count were measured in these children. Sixty age-matched healthy children were enrolled as the control group.ResultsFeNO values were signiifcantly higher in the acute exacerbation group (24.4 ppb) than in the remission group (18.0 ppb) and the control group (13.7 ppb) (P<0.05). The FeNO values in the remission group were signiifcantly higher than in the control group (P<0.05). FeNO values were not signiifcantly correlated with peripheral blood EOS count and lung function parameters (PEF, TEF25, TEF50, and TEF75) .Conclusions Measurement of FeNO is useful to evaluate the disease activity in children with asthma aged 1 to 3 years, but the FeNO values are not correlated with peripheral blood EOS count and lung function.关键词
哮喘/呼出气一氧化氮/肺功能/外周血嗜酸粒细胞计数/相关性/儿童Key words
Asthma/Fractional exhaled nitric oxide/Lung function/Peripheral blood eosinophil count/Correlation/Child引用本文复制引用
田文秋,安淑华,李金英..1~3岁哮喘患儿呼出气一氧化氮水平与外周血嗜酸性粒细胞计数及肺功能的相关性[J].中国当代儿科杂志,2015,(4):317-320,4.基金项目
河北省医学适用技术跟踪项目［GL2011-11］。 （）
