中国当代儿科杂志Issue(4)：379-383,5.DOI:10.7499/j.issn.1008-8830.2015.04.018
儿童青少年期起病精神分裂症患者的临床特征与认知功能的关系
Relationship between clinical features and cognitive function in patients with childhood and adolescence-onset schizophrenia
摘要
Abstract
ObjectiveTo explore the factors influencing cognitive functions in patients with childhood and adolescence-onset schizophrenia.MethodsThe clinical data of 78 patients with childhood and adolescence-onset schizophrenia who met with the criteria of ICD-10 for schizophrenia were retrospectively reviewed. The cognitive functions were evaluated by the Chinese Wechsler Intelligence Scale for Children (C-WISC), the Wisconsin Card Sorting Test (WCST), digit span backward and P300. The clinical symptoms were evaluated by the Positive and Negative Syndrome Scale (PANSS).ResultsThe patients with a lower education level or earlier onset of age had a longer P3 latency at the P300Fz area. The patients with a higher parental education level had higher scores of full intelligence quotient (FIQ), verbal intelligence quotient (VIQ), performance intelligence quotient (PIQ), conceptual level and completed categories of WCST and backward numeric order reciting. The patients with higher PANSS negative subscale scores had lower scores of FIQ, VIQ, PIQ, completed categories and conceptual level of WCST and backward numeric order reciting. The patients with a longer stabilization time had higher backward numeric order reciting scores. ConclusionsThe severity of negative symptoms of the patients and the educational level of their parents are major factors inlfuencing cognitive functions in patients with childhood and adolescence-onset schizophrenia.关键词
精神分裂症/认知功能/临床特征/儿童青少年Key words
Schizophrenia/Cognitive function/Clinical feature/Child and adolescent引用本文复制引用
曹阳,康传媛,万帅,都萌萌,丁凯景,李雪蓉..儿童青少年期起病精神分裂症患者的临床特征与认知功能的关系[J].中国当代儿科杂志,2015,(4):379-383,5.基金项目
国家自然科学基金（编号81460218）；云南省高层次卫生技术人才培养专项经费（编号D-201238）；2012云南省卫生科技计划项目（2012ws0008）。 （）
