RAD50基因多态性与儿童急性淋巴细胞白血病的相关性OA北大核心CSCDCSTPCD
Association between polymorphism of RAD50 gene and acute lymphoid leukemia in children
目的：探讨RAD50基因的SNP位点（rs17166050）的多态性与我国中部地区儿童急性淋巴细胞白血病（ALL）的相关性。方法177例来自湖北武汉或其周边地区的ALL患儿和232例健康儿童作为研究对象。177例患儿中，标危66例，中危69例，高危42例。利用PCR-RFLP的方法检测RAD50基因SNP位点多态性，研究该多态性与ALL易感性及临床危险度的相关性。结果 ALL组的RAD50基因SNP位点的基因型（AA、GA、GG）分布与对照组相比…查看全部>>
ObjectiveTo investigate the association between single nucleotide polymorphism (SNP) (rs17166050) in RAD50 gene and acute lymphoid leukemia (ALL) in children.MethodsA total of 177 ALL children from Wuhan and surrounding areas and 232 healthy children were selected. The numbers of standard-risk, medium-risk, and high-risk children were 66, 69, and 42, respectively. The genotypes of SNP in RAD50 gene were determined using PCR-RFLP, and the relationship of the …查看全部>>
李雯;徐之良
武汉大学人民医院儿科，湖北 武汉 430060武汉大学人民医院儿科，湖北 武汉 430060
白血病RAD50基因多态性危险度儿童
LeukemiaRAD50 genePolymorphismRiskChild
《中国当代儿科杂志》 2015 (5)
469-471,3
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