中国当代儿科杂志Issue(5)：492-495,4.DOI:10.7499/j.issn.1008-8830.2015.05.016
EB病毒感染患儿CD163表达及其临床意义
Expression of CD163 in children with Epstein-Barr virus infection
陈燕丽 1陈福雄 2邓长柏 1夏波 2吴丽萍 2吴泽霖 2卢慧敏2
作者信息
- 1. 广州医科大学附属第五医院儿科，广东 广州 510700
- 2. 广州医科大学附属第一医院儿科，广东 广州 510120
- 折叠
摘要
Abstract
ObjectiveTo study the clinical signiifcance of CD163 in the diagnosis and the evaluation of severity and prognosis of childhood hemophagocytic lymphohistiocytosis (HLH).MethodsNinety-four children were classiifeied into Epstein-Barr virus (EBV)-positive (n=55) and EBV-negative groups (n=39; control group). The EBV-positive group was subgrouped into infectious mononucleosis (IM;n=47) and HLH (n=8). Serum levels of soluble CD163 were measured using ELISA. Expression of CD163 on mononuclear cells was detected by flow cytometry. ResultsThe serum levels of soluble CD163 were > 10 000 ng/mL in all eight HLH patients (> 30 000 ng/mL in 3 cases). The mean serum levels of soluble CD163 in the HLH group were signiifcantly higher than in the control and IM groups (P<0.05). The serum levels of soluble CD163 in EBV-positive children were positively correlated with EBV-DNA copies and serum levels of ferritin and LDH, but were negatively correlated with white blood cell count, neutrophil count, hemoglobin and platelet count. The follow-up after treatment for three HLH patients showed that serum levels of soluble CD163 were signiifcantly reduced, but the soluble CD163 levels rebounded in one patient who was complicated by fungal pneumonia infection.ConclusionsThe levels of serum soluble CD163 may be related to the severity in children with HLH. The EBV-positive children with soluble CD163 levels >10 000 ng/mL should be considered the possibility of HLH.关键词
EB病毒/噬血细胞综合征/CD163/儿童Key words
Epstein-Barr virus/Hemophagocytic lymphohistiocytosis/CD163/Child引用本文复制引用
陈燕丽,陈福雄,邓长柏,夏波,吴丽萍,吴泽霖,卢慧敏..EB病毒感染患儿CD163表达及其临床意义[J].中国当代儿科杂志,2015,(5):492-495,4.
