中国当代儿科杂志Issue(7)：687-691,5.DOI:10.7499/j.issn.1008-8830.2015.07.009
弓形虫感染患儿淋巴细胞亚群及干扰素-γ的变化及临床意义
Changes in lymphocyte subsets and serum IFN-γ levels in children with toxoplasma infection
章海峻 1陆春琴 2方彩文1
作者信息
- 1. 绍兴市中心医院 儿科，浙江 绍兴 312030
- 2. 绍兴市中心医院 检验科，浙江 绍兴 312030
- 折叠
摘要
Abstract
ObjectiveTo study the changes and significance of lymphocyte sunsets and serum interferon-γ(IFN-γ) levels in children with toxoplasma infection.MethodsThirty-four children who were newly diagnosed with toxoplasma infection (TOX-IgM+ group) between January 2011 and April 2014, 12 children who had ever been diagnosed with toxoplasma infection (TOX-IgG+ group), and 54 healthy children (control group) were enrolled. The percentages of CD4+, CD8+, CD19+ and NK cells in peripheral blood lymphocytes were detected by lfow cytometry. Serum levels of IFN-γ were measured using ELISA.ResultsThe percentages of CD4+ cells and the CD4+/CD8+ ratio in the TOX-IgM+ group were signiifcantly lower than in the TOX-IgG+ and control groups, while the percentages of CD8+ and NK cells and serum IFN-γ levels were signiifcantly higher than in the other two groups (P<0.05). The TOX-IgG+ group had higher serum IFN-γ levels than the control group (P<0.05). There was a positive correlation between the percentage of CD8+ cells and serum IFN-γ levels in the TOX-IgM+ group (r=0.756;P<0.05).ConclusionsCD4+, CD8+ and NK cells may play important roles in the resistance against toxoplasma infection by promoting the secretion of cytokines.关键词
淋巴细胞亚群/γ干扰素/弓形虫/儿童Key words
Lymphocyte subsets/Interferon-γ/Toxoplasma gondii/Child引用本文复制引用
章海峻,陆春琴,方彩文..弓形虫感染患儿淋巴细胞亚群及干扰素-γ的变化及临床意义[J].中国当代儿科杂志,2015,(7):687-691,5.
