中国当代儿科杂志Issue(7)：692-697,6.DOI:10.7499/j.issn.1008-8830.2015.07.010
哮喘患儿对长程控制治疗反应性的差异及其相关因素分析
Related factors for asthmatic children's responses to long-term treatment
摘要
Abstract
ObjectiveTo study the changes in pulmonary function and fractional exhaled nitric oxide in exhaled breath (FeNO) in asthmatic children who have different responses to regular treatment.MethodsA total of 52 asthmatic children who had a good compliance with regular stepped control treatment were selected as subjects. They were followed up every three months to evaluate the asthma control level, pulmonary ventilation function, and FeNO for 9 months. Besides, medications for asthma control were recorded.ResultsAt three follow-up points (months 3, 6, and 9), the percentage of asthmatic children who used the ifrst or the second level of control treatment in the stable group (with stable response to the treatment) was signiifcantly higher than in the unstable group (with unstable response to the treatment) (P<0.05), while the percentage of asthmatic children who used the third level of control treatment in the stable group was signiifcantly lower than in the unstable group (P<0.05). At the three follow-up points, the stable group had a significantly higher ratio of forced expiratory volume in 1 second to forced vital capacity (FEV1/FVC) than the unstable group (P<0.05); at the 3-month and 9-month follow-up points, the stable group had a signiifcantly higher percentage of predicted maximum mid-expiratory flow (MMEF%) than the unstable group (P<0.05); at the initial evaluation and 3-month follow-up point, the stable group had a signiifcantly higher FeNO than the unstable group (P<0.05).ConclusionsContinuously monitoring FEV1/FVC, MMEF% and FeNO is useful in the early evaluation of the responses to treatment in children with asthma.关键词
哮喘/肺功能/呼出气一氧化氮浓度/儿童Key words
Asthma/Pulmonary function/Fractional exhaled nitric oxidein in exhaled breath/Child引用本文复制引用
刘晓颖,王静,王群,任亦欣,刘永革,苗青,李珍,向莉..哮喘患儿对长程控制治疗反应性的差异及其相关因素分析[J].中国当代儿科杂志,2015,(7):692-697,6.基金项目
国家自然科学基金（81100022）；北京市科技专项（Z131100006813044）；国家科技支撑计划（2012BAI03B02）。 （）
