中国肺癌杂志Issue(8)：625-634,10.DOI:10.3779/j.issn.1009-3419.2014.08.08
肺癌细胞中HGF/c-Met信号通路的异常调控及其靶向药物研究进展
Dysregulation of HGF/c-Met Signal Pathway and Their Targeting Drugs in Lung Cancer
摘要
Abstract
C-MET is a coding product of proto oncogene c-MET, hepatocyte growth factor (HGF) receptor with tyrosine kinase activity. hTe abnormal expression of c-Met gene is correlated with the tumorigenesis and development of lung cancer. Once the tyrosine kinase is activated by the interaction between the HGF ligand and the TK receptor, and the activated kinase will promote the cell proliferation, angiogenesis, invasion and metastasis of different tumors, as well as lung cancer. hTe targeted therapy to HGF/c-Met signal pathway is a new highlight in the treatments of lung cancer. In this review, we will discuss the dysregulation of HGF/c-Met signal pathway in lung cancer and the new progress for the targeted drugs to this pathway.关键词
c-Met/HGF/靶向药物/肺肿瘤Key words
c-Met/HGF/Targeting Drugs/Lung neoplasms分类
医药卫生引用本文复制引用
李永文(综述),刘红雨,陈军(审校)..肺癌细胞中HGF/c-Met信号通路的异常调控及其靶向药物研究进展[J].中国肺癌杂志,2014,(8):625-634,10.基金项目
国家自然科学基金（No.81172233, No.81372306）、天津市自然科学基金重点项目（No.12JCZDJC24400）、天津市自然科学基金项目（No.13JCYBJC22600）、天津市科委抗癌重大专项攻关计划（No.12ZCDZSY16100）、教育部新世纪人才基金（No.NCET-10-0956）的资助。 （）
